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Raczynska

dr hab. Katarzyna Dorota Raczyńska, Prof. UAM

Laboratory of RNA Processing

A209
doracz@amu.edu.pl
ORCID
www

Research Interests

> The role of non-coding RNAs in human cells

> Regulation of transposable elements involving U7 snRNA

> The impact of FUS protein and ALS-FUS mutants on translation and genome stability

> Pathogenesis of the neurodegenerative disease ALS

Assistant Professors and Postdoctoral Fellows

Bieluszewska
dr Anna Bieluszewska

annastec@amu.edu.pl
Room: A213

Technical staff

Raczynska (6 of 6)
mgr Anna Kozłowska

ak20663@amu.edu.pl
Room: A226

PhD Students

Pasieka
mgr Robert Pasieka

robert.pasieka@amu.edu.pl
Room: A226

Swiergiel
mgr Patrycja Świergiel

patrycja.swiergiel@amu.edu.pl
Room: A227

Stopczyk
mgr Zuzanna Stopczyk

zuzana.stopczyk@amu.edu.pl
Room: A227

Kapuscinska
mgr Iga Kapuścińska

iga.kapuscinska@amu.edu.pl
Room: A227

Grants

OPUS 25: 2023/49/B/NZ5/01976

„Translation-related pathway and activated retrotransposons underlying the neurodegenerative disease ALS related to mutations in the FUS gene”

PRELUDIUM 22: 2023/49/N/NZ5/00607

„Activation of retrotransposons underlying neurodegenerative disease ALS related to mutations in FUS protein”

Selected publications

  1. Novel function of U7 snRNA in the repression of HERV1/LTR12s and lincRNAs in human cells, Plewka P., Szczesniak M.W., Stepien A., Pasieka R., Wanowska E., Makalowska I, Raczynska K.D., Nucleic Acids Research, 2025, 52, 10504–10519. [LINK⇒]
  2. Imprinted small nucleolar RNAs: Missing link in development and disease?”, Gawade, K., & Raczynska K. D., WIREs RNA, 2023, 15, e1818. [LINK⇒]
  3. FUS regulates a subset of snoRNA expression and modulates the level of rRNA modifications, Gawade K., Plewka P., Häfner S.J., Lund A.H., Marchand V., Motorin Y., Szczesniak M.W., Raczynska K.D., Sci. Rep., 2023, 13, 2974. [LINK⇒]
  4. Role of Long Intergenic Noncoding RNAs in Cancers with an Overview of MicroRNA Binding, Pasieka R., Zasoński G., Raczyńska K.D., Mol. Diagn. Ther., 2022, 27, 29–47. [LINK⇒]
  5. The Novel Role of hnRNP UL1 in Human Cell Nucleoli, Cichocka M., Karlik A., Plewka P., Gawade K., Stępień A., Świergiel P., Gadgil A., Raczyńska K.D., Int. J. Biol. Sci., 2022, 18, 4809-4823. [LINK⇒]
  6. Long Intergenic Noncoding RNAs Affect Biological Pathways Underlying Autoimmune and Neurodegenerative Disorders, Plewka P., Raczynska K.D., Mol. Neurobiol., 2022, Sep, 59, 5785-5808. [LINK⇒]
  7. Context-Dependent Regulation of Gene Expression by Non-Canonical Small RNAs, Plawgo K., Raczynska K.D., Non-Coding RNA, 2022, 8, 29. [LINK⇒]
  8. ALS-linked FUS mutants affect the localization of U7 snRNP and replication-dependent histone gene expression in human cells, Gadgil A., Walczak A., Stępień A., Mechtersheimer J., Nishimura A.L., Shaw C.E., Ruepp M.D., Raczyńska K.D., Sci. Rep., 2021, 11, 11868.[LINK⇒]
  9. U7 snRNA: A tool for Gene therapy, Gadgil A., Raczynska K.D., J Gene Med., 2021, e3321. [LINK⇒]
  10. FUS/TLS contributes to replication-dependent histone gene expression by interaction with U7 snRNP, Raczyńska K.D., Ruepp M.D., Brzek A., Romeo V., Rindlisbacher B., Heller M., Szweykowska-Kulinska Z., Jarmolowski A., Schümperli D., Nucleic Acids Res., 2015, 43, 9711-9728. [LINK⇒]