dr Rajani Gudipati
Laboratory of Proteases and Gene Expression (PAGE)
Research Interests
> Role of picd-1 in transposon silencing and genome maintenance
> Argonaute regulation by a protease
> The DPPIV proteases and their role in repeat expansion disorders
> PUF-9’s function in reproduction
Assistant Professors and Postdoctoral Fellows
dr Ilkin Aygun Soyalp
ilkin.aygunsoyalp@amu.edu.pl
Room: A240
dr Hasan Ali
hasan.ali@amu.edu.pl
Room: A240
dr Aditya Trivedi
aditya.trivedi@amu.edu.pl
Room: A240
Technical staff
dr inż. Noor Ramzi
Lab Menager
noor.ramzi@amu.edu.pl
Room: A240
PhD Students
mgr Ankit Roy
ankit.roy@amu.edu.pl
Room: A240
mgr Damini Saha
damini.saha@amu.edu.pl
Room: A240
mgr Afzal Amanullah
afzal.amanullah@amu.edu.pl
Room:A240
Grants
SONATA BIS: 2021/42/E/NZ1/00336
“Role of DPPIV family proteases in transposon silencing and genome maintenance”
OPUS: 2022/45/B/NZ2/02183
“Mechanistic Understanding of picd-1 in Transposon Silencing and Genome Maintenance”
Miniatura: 2024/08/X/NZ1/01122
“Określenie roli białka Pumilio PUF-9 w rozwoju linii płciowej”
Selected publications
Dipeptidyl peptidase DPF-3 is a gatekeeper of microRNA Argonaute compensation in animals, L.-M. Harvey, P.-M. Frédérick, R. K. Gudipati, P. Michaud, F. Houle, D. Young, C. Desbiens, S. Ladouceur, A. Dufour, H. Großhans, M. J. Simard, Nat. Commun., 2025, 16, 2738. [LINK⇒]
Deep quantification of substrate turnover defines protease subsite cooperativity, R. K. Gudipati, D. Gaidatzis, J. Seebacher, S. Muehlhaeusser, G. Kempf, S. Cavadini, D. Hess, C. Soneson, H. Großhans, Mol. Syst. Biol., 2024, 20, 1303-1328. [LINK⇒]
Protease-mediated processing of Argonaute proteins controls small RNA association, R. K. Gudipati, K. Braun, F. Gypas, D. Hess, J. Schreier, S. H. Carl, R. F. Ketting, H. Großhans, Mol. Cell., 2021, 81, e2388. [LINK⇒]
Extensive degradation of RNA precursors by the exosome in wild-type cells, R. K. Gudipati, Z. Xu, A. Lebreton, B. Séraphin, L. M. Steinmetz, A. Jacquier, D. Libri, Mol. Cell., 2012, 48, 409-421. [LINK⇒]